Shahrekord University of Medical Sciences Journal of Multidisciplinary Care 2783-3852 11 4 2022 12 30 A massive stroke in a pregnant woman following COVID-19 infection: A case report 206 208 10.34172/jmdc.2022.1128 EN Hatav Ghasemi-Tehrani https://orcid.org/0000-0003-3112-8085 Maryam Allahdadian https://orcid.org/0000-0001-5128-9578 Maryam Vizheh https://orcid.org/0000-0002-7780-8580 Maryam Dehghan https://orcid.org/0000-0002-7497-7012 Maryam Hashemi https://orcid.org/0000-0001-9692-1485 Journal Article 10.34172/jmdc.2022.1128 2022 11 03 2022 12 20 Background and aims: COVID-19 infection increases the risk of pathological thrombotic events in venous and arterial circulation. COVID-19 patients are reported, a wide range of neurovascular symptoms is highlighted, such as cerebral vascular accidence. This study aimed to report a massive stroke in a pregnant woman with COVID-19 infection. Case Report: We report a 41-year-old pregnant woman, gravid 5 para 2 living 2 abortion 2 at gestational age 22 weeks and 4 days with Covid-19 infection, which developed into a massive stroke in the Basilar artery despite receiving a therapeutic dosage of Enoxaparin Sodium. Conclusion: The possibility of thrombosis should be considered in COVID-19 patients with symptoms indicating an increase in intracranial pressure (ICP) such as decreased consciousness, strabismus, and agitation. Considering the higher risk of thrombotic events in COVID-19 patients, cerebral venous sinus thrombosis (CVST) could be a possible consequence. Thus, the precise observation of neurologic manifestations in covid-19 patients, especially in pregnant women, is recommended.